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BDSM (bondage and control, dominance and distribution, and sadism and masochism) increasingly receives attention through the scientific community. Where previous research efforts mainly dedicated to epidemiologic traits, emotional and biologic facets driving BDSM choices have recently gained interest as well.To bring together most of the existing literature that is scientific BDSM from the biopsychosocial perspective.Based from the PRISMA recommendations, the present systematic review brings together all the existing literature on BDSM from the biopsychosocial viewpoint.Prevalence rates of BDSM interests were examined within the literary works, plus the associations between BDSM passions on one side and personality faculties, unfavorable youth experiences, training amounts, intimate orientations and biological markers regarding the other.